HomeAvailabilityGuidelinesOff Label UseDangersLinksBibliography

“Women are not dying because of diseases we cannot treat. They are dying because societies have yet to make the decision that their lives are worth saving.”

Prof. Mahmoud Fathalla

This independent site has been set up to distribute dosage guidlines for the use of misoprostol in obstetrics and gynaecology. The correct dosage varies greatly according to gestation, indication and route of administration - using the correct dosage is vital for success and to prevent complications. 

Recommended doses of Misoprostol (Cytotec®) are provided in this site along with instructions for use. A simplified dosage chart for non-doctors is also available here.

Misoprostol is an E1 prostaglandin analogue which has been approved in more than 85 countries since its first marketing in 1985It was originally approved for the treatment of gastric ulcer, but increasing numbers of countries now have generic versions with full license for use in pregnancy.


For comments on the site, e-mail misoprostol@aon.at

Dosage recommendations in Russian are also available

Misoprostol dosage graph

Figure 1: Safe single doses of vaginal misoprostol for producing uterine contractions at various gestations.  For the first trimester 800µcg 24 hourly can be safely used.  In the second trimester 200µcg 12 hourly is a common dose, whilst beyond 24 weeks 25µcg 6 hourly is usually used.  If a higher dose than this is used, then uterine hyperstimulation with uterine rupture or fetal distress might be the result.